Expression of a β-Defensin mRNA, Lingual Antimicrobial Peptide, in Bovine Mammary Epithelial Tissue Is Induced by Mastitis-Reference-Cited by-同舟云学术

Expression of a β-Defensin mRNA, Lingual Antimicrobial Peptide, in Bovine Mammary Epithelial Tissue Is Induced by Mastitis

Published:2004-12 Issue:12 Volume:72 Page:7311-7314
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Swanson Kara¹²,Gorodetsky Stas³,Good Laura¹,Davis Stephen¹,Musgrave David²,Stelwagen Kerst¹,Farr Vicki¹,Molenaar Adrian¹

Affiliation:

1. AgResearch, Ruakura Research Centre

2. Department of Biological Sciences, University of Waikato, Hamilton, New Zealand

3. Engelhardt Institute of Molecular Biology, RAS, Moscow, Russia

Abstract

ABSTRACT The expression of a β-defensin, the lingual antimicrobial peptide (LAP), in response to mastitis was investigated by real-time PCR of RNA from mastitic and control udder quarters. There was a positive relationship between somatic cell count in milk and LAP expression. In situ hybridization showed that LAP mRNA was expressed in epithelial cells of mastitic tissue. These results suggest that LAP plays a role in the innate immune response to mastitis.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.72.12.7311-7314.2004

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