Antibody Landscape Analysis following Influenza Vaccination and Natural Infection in Humans with a High-Throughput Multiplex Influenza Antibody Detection Assay

Author:

Li Zhu-Nan1,Liu Feng1,Gross F. Liaini1,Kim Lindsay23,Ferdinands Jill1,Carney Paul1,Chang Jessie1,Stevens James1,Tumpey Terrence1,Levine Min Z.1ORCID

Affiliation:

1. Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

2. Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

3. U.S. Public Health Service, Rockville, Maryland, USA

Abstract

Repeated influenza vaccination and natural infections generate complex immune profiles in humans that require antibody landscape analysis to assess immunity and evaluate vaccines. However, antibody landscape analyses are difficult to perform using traditional assays.

Funder

HHS | Centers for Disease Control and Prevention

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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