A Highly Conserved Neutralizing Epitope on Group 2 Influenza A Viruses

Author:

Ekiert Damian C.1,Friesen Robert H. E.2,Bhabha Gira1,Kwaks Ted2,Jongeneelen Mandy2,Yu Wenli1,Ophorst Carla2,Cox Freek2,Korse Hans J.W.M.2,Brandenburg Boerries2,Vogels Ronald2,Brakenhoff Just P.J.2,Kompier Ronald2,Koldijk Martin H.2,Cornelissen Lisette A.H.M.3,Poon Leo L. M.4,Peiris Malik4,Koudstaal Wouter2,Wilson Ian A.15,Goudsmit Jaap2

Affiliation:

1. Department of Molecular Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

2. Crucell Holland BV, Archimedesweg 4-6, 2301 CA Leiden, Netherlands.

3. Central Veterinary Institute, Wageningen University, Houtribweg 39, 8221 RA Lelystad, Netherlands.

4. State Key Laboratory of Emerging Infectious Diseases and Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China.

5. Skaggs Institute for Chemical Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

Abstract

An antibody against a conserved epitope broadly neutralizes group 2 influenza viruses.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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