A Clinical Study Provides the First Direct Evidence That Interindividual Variations in Fecal β-Lactamase Activity Affect the Gut Mycobiota Dynamics in Response to β-Lactam Antibiotics-Reference-Cited by-同舟云学术

A Clinical Study Provides the First Direct Evidence That Interindividual Variations in Fecal β-Lactamase Activity Affect the Gut Mycobiota Dynamics in Response to β-Lactam Antibiotics

Published:2022-12-20 Issue:6 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Delavy Margot¹,Burdet Charles²³,Sertour Natacha¹,Devente Savannah⁴,Docquier Jean-Denis⁴^ORCID,Grall Nathalie²,Volant Stevenn⁵,Ghozlane Amine⁵,Duval Xavier²⁶,Mentré France²³,d’Enfert Christophe¹^ORCID,Bougnoux Marie-Elisabeth¹⁷

Affiliation:

1. Institut Pasteur, Université Paris Cité, INRAE USC2019, Unité Biologie et Pathogénicité Fongiques, Paris, France

2. Université Paris Cité, IAME, INSERM, Paris, France

3. AP-HP, Département d’Epidémiologie, Biostatistique et Recherche Clinique, Hôpital Bichat, Paris, France

4. Università di Siena, Dipartimento di Biotecnologie Mediche, Siena, Italy

5. Institut Pasteur, Université Paris Cité, Bioinformatics and Biostatistics Hub, Paris, France

6. Clinical investigation center, INSERM 1425, IAME, Hôpital Bichat, Assistance Publique des Hôpitaux de Paris (APHP), Université Paris Cité, Paris, France

7. Unité de Parasitologie-Mycologie, Service de Microbiologie Clinique, Hôpital Necker-Enfants-Malades, Assistance Publique des Hôpitaux de Paris (APHP), Paris, France

Abstract

Fungal infections are redoubtable healthcare-associated complications in immunocompromised patients. Particularly, the commensal intestinal yeast Candida albicans causes invasive infections in intensive care patients and is, therefore, associated with high mortality.

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.02880-22

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