Emergence of Tn 1999.7 , a New Transposon in bla OXA-48 -Harboring Plasmids Associated with Increased Plasmid Stability-Reference-Cited by-同舟云学术

Emergence of Tn 1999.7 , a New Transposon in bla _OXA-48 -Harboring Plasmids Associated with Increased Plasmid Stability

Published:2022-11-15 Issue:11 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Sattler Janko¹²^ORCID,Tsvetkov Tsvetan¹²,Stelzer Yvonne³,Schäfer Sina¹²,Sommer Julian⁴,Noster Janina³^ORCID,Göttig Stephan⁴,Hamprecht Axel¹²³^ORCID

Affiliation:

1. Institute for Medical Microbiology, Immunology and Hygiene, University Hospital Cologne and Faculty of Medicine, University of Cologne, Cologne, Germany

2. DZIF (German Centre for Infection Research), Partner Site Bonn-Cologne, Cologne, Germany

3. Institute for Medical Microbiology and Virology, University of Oldenburg and Klinikum Oldenburg, Oldenburg, Germany

4. Institute for Medical Microbiology and Infection Control, Hospital of Johann Wolfgang Goethe University, Frankfurt, Germany

Abstract

OXA-48 is the most common carbapenemase in Enterobacterales in Germany and many other European countries. Depending on the genomic location of bla OXA-48 , OXA-48-producing isolates vary in phenotype and intra- and interspecies transferability of bla OXA-48 . In most bacterial isolates, bla OXA-48 is located on one of seven variants of Tn 1999 (Tn 1999.1 to Tn 1999.6 and invTn 1999.2 ).

Funder

German centre for infection research

KoelnFortune Programme

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00787-22

Reference45 articles.

1. The Global Ascendency of OXA-48-Type Carbapenemases

2. Integrated chromosomal and plasmid sequence analyses reveal diverse modes of carbapenemase gene spread among Klebsiella pneumoniae