Nucleotide sequence of a plasmid-mediated cephalosporinase gene (blaLAT-1) found in Klebsiella pneumoniae

Author:

Tzouvelekis L S1,Tzelepi E1,Mentis A F1

Affiliation:

1. Department of Bacteriology, Hellenic Pasteur Institute, Athens, Greece.

Abstract

The nucleotide sequence of the gene encoding a novel cephalosporinase (LAT-1), carried by a non-self-transferable plasmid from Klebsiella pneumoniae, has been determined. It was found that the sequence shares a high degree of homology with the Citrobacter freundii OS60 ampC structural gene.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference15 articles.

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2. Bauernfeind A. P. Mangold S. Schweighart G. H. Miller K J. Shaw H. Giamarellou and K. Dornbush. 1992. Molecular analysis of a transferable cephamycinase in Klebsiella pneumoniae. Program Abstr. 32nd Intersci. Conf. Antimicrob. Agents Chemother. abstr. 1268.

3. Cloning and sequence analysis of blaBIL-l, a plasmid-mediated class C P-lactamase gene in Escherichia coli BS;Fosberry A. P.;Antimicrob. Agents Chemother.,1994

4. Plasmid-mediated AmpC-type P-lactamase isolated from Kiebsiella pneumoniae confers resistance to broad-spectrum ,B-lactams, including moxalactam;Horii T.;Antimicrob. Agents Chemother.,1993

5. Sequence of the Citrobacter freundii OS60 chromosomal ampC P-lactamase gene;Lindberg F.;Eur. J. Biochem.,1986

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