Enhanced Carbapenem Resistance through Multimerization of Plasmids Carrying Carbapenemase Genes-Reference-Cited by-同舟云学术

Enhanced Carbapenem Resistance through Multimerization of Plasmids Carrying Carbapenemase Genes

Published:2021-06-29 Issue:3 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Abe Ryuichiro¹²,Akeda Yukihiro¹³⁴⁵^ORCID,Sugawara Yo¹⁵^ORCID,Matsumoto Yuki⁶,Motooka Daisuke⁶,Kawahara Ryuji⁷,Yamamoto Norihisa³⁴,Tomono Kazunori³⁴,Iida Tetsuya¹²⁶,Hamada Shigeyuki¹

Affiliation:

1. Japan-Thailand Research Collaboration Center on Emerging and Re-emerging Infections, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan

2. Department of Bacterial Infections, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan

3. Division of Infection Control and Prevention, Osaka University Hospital, Suita, Japan

4. Department of Infection Control and Prevention, Graduate School of Medicine, Osaka University, Osaka, Japan

5. National Institute of Infectious Diseases, Tokyo, Japan

6. Department of Infection Metagenomics, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan

7. Department of Microbiology, Osaka Institute of Public Health, Osaka, Japan

Abstract

We demonstrated the multimerization of plasmids harboring carbapenemase genes, and multimeric plasmids of various discrete sizes existed in a host bacterial cell of Escherichia coli . Plasmid multimerization along with increased copy numbers of carbapenemase genes resulted in enhanced carbapenemase resistance, which was readily accelerated by an overnight preexposure to meropenem. This mechanism may lead to treatment failure in clinical settings after the initiation of antimicrobial therapy.

Funder

Japan Agency for Medical Research and Development

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.00186-21

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