Clinical comparison of single-oral-dose cefuroxime axetil and amoxicillin with probenecid for uncomplicated gonococcal infections in women

Author:

Baddour L M1,Gibbs R S1,Mertz G1,Cocchetto D M1,Noble R C1

Affiliation:

1. Department of Medicine, University of Missouri-Columbia 65212.

Abstract

Four hundred sixty-six female patients were enrolled in a randomized study that compared the clinical efficacies of single oral doses of cefuroxime axetil and amoxicillin with probenecid in the treatment of uncomplicated gonorrhea. Two hundred ninety-five patients had culture-positive gonococcal infections and completed the investigation. Cure rates for the patients treated with cefuroxime axetil and those treated with amoxicillin with probenecid were high (greater than 95%) for genitorectal infections. Pharyngeal infections, however, were not uniformly eradicated by either cefuroxime axetil (60%) or amoxicillin with probenecid (64%). Approximately 13% of each patient group suffered adverse events, which were gastrointestinal in the majority and were transient. Compared with amoxicillin plus probenecid, cefuroxime axetil in a single oral dose was an equally safe and effective drug for the treatment of uncomplicated gonorrhea in women caused by penicillin-susceptible strains.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference20 articles.

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2. Comparative clinical efficacy of single oral doses of cefuroxime axetil and amoxicillin in uncomplicated gonococcal infections;Fong I. W.;Antimicrob. Agents Chemother.,1986

3. Cefuroxime and postgonococcal urethritis;Fowler W.;Proc. R. Soc. Med.,1977

4. Clinical experience in the use of cefuroxime in gonorrhoea;Fowler W.;Br. J. Vener. Dis.,1978

5. Cefuroxime axetil for treatment of uncomplicated gonorrhea;Gottlieb A.;Antimicrob. Agents Chemother.,1986

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