Affiliation:
1. Institute of Virology and AIDS Research, The First Hospital of Jilin University, Changchun, China
2. Beijing Institute of Radiation Medicine, Beijing, China
3. School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, China
Abstract
Human enterovirus (EV) pathogens cause various contagious diseases such as hand, foot, and mouth disease, encephalitis, myocarditis, acute flaccid myelitis, pneumonia, and bronchiolitis, which have become serious health threats. However, except for the EV71 vaccine on the market, there are no effective strategies to prevent and treat other EV pathogen infections. Therefore, broad-spectrum anti-EV drugs are urgently needed. In this study, we demonstrated that FNC, a small nucleoside analog inhibitor that has been demonstrated to be a potent inhibitor of HIV and entered into a clinical phase II trial in China, potently inhibits the viral replication of a multitude of EVs at the nanomolar level. Further investigation revealed that FNC inhibits positive- and negative-strand RNA synthesis of EVs by interacting and interfering with the activity of EV71 viral RNA-dependent RNA polymerase (3D
pol
). Our findings demonstrate for the first time that FNC is an effective broad-spectrum inhibitor for human EV pathogens.
Funder
Chinese Ministry of Science and Technology
Science and Technology Department of Jilin Province
Key Laboratory of Molecular Virology, Jilin Province
Norman Bethune Program of Jilin University
National Natural Science Foundation of China
Jilin Provincial Health and Family Planning Commission
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
Cited by
45 articles.
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