Fully Continuous Flow Synthesis of 2′-Deoxy-2′-fluoro-arabinoside: A Key Intermediate of Azvudine-Reference-Cited by-同舟云学术

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Fully Continuous Flow Synthesis of 2′-Deoxy-2′-fluoro-arabinoside: A Key Intermediate of Azvudine

Published:2024-07-31 Issue:8 Volume:28 Page:3273-3283
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Chen Yan¹,Sun Yongcheng¹,Xu Yufang¹^ORCID,Qian Xuhong¹^ORCID,Zhu Weiping¹²^ORCID

Affiliation:

1. State Key Laboratory of Bioreactor Engineering; Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, P. R. China

2. Engineering Research Center of Pharmaceutical Process Chemistry, Ministry of Education, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, P. R. China

Funder

National Key Research and Development Program of China

Science and Technology Commission of Shanghai Municipality

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.4c00166

Reference45 articles.

1. FNC, a novel nucleoside analogue inhibits cell proliferation and tumor growth in a variety of human cancer cells

2. The pyrimidine analog FNC inhibits cell proliferation and viral protein synthesis in HTLV-1-infected cells

3. Synthesis and anti-HIV activity of 2′-deoxy-2′-fluoro-4′-C-ethynyl nucleoside analogs

4. Novel nucleoside analogue FNC is effective against both wild-type and lamivudine-resistant hepatitis B virus clinical isolates

5. Antiviral activity of FNC, 2′-deoxy-2′-β-fluoro-4′-azidocytidine, against human and duck HBV replication

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