A Single Nucleotide Change in the polC DNA Polymerase III in Clostridium thermocellum Is Sufficient To Create a Hypermutator Phenotype-Reference-Cited by-同舟云学术

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A Single Nucleotide Change in the polC DNA Polymerase III in Clostridium thermocellum Is Sufficient To Create a Hypermutator Phenotype

Published:2022-01-11 Issue:1 Volume:88 Page:
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Lanahan Anthony¹²,Zakowicz Kamila¹,Tian Liang¹²,Olson Daniel G.¹²^ORCID,Lynd Lee R.¹²

Affiliation:

1. Thayer School of Engineering at Dartmouth College, Hanover, New Hampshire, USA

2. Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA

Abstract

Cellulosic biofuels are a promising approach to decarbonize the heavy-duty-transportation sector. A longstanding barrier to cost-effective cellulosic biofuel production is the recalcitrance of the material to solubilization.

Funder

HHS | NIH | National Cancer Institute

U.S. Department of Energy

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/AEM.01531-21

Reference52 articles.

1. Cellulosic ethanol: status and innovation

2. From cellulosomes to cellulosomics

3. Thermophilic whole‐cell degradation of polyethylene terephthalate using engineered Clostridium thermocellum

4. The emergence of adaptive laboratory evolution as an efficient tool for biological discovery and industrial biotechnology

5. Sequence analysis and phenotypes of five temperature sensitive mutator alleles of dnaE, encoding modified α-catalytic subunits of Escherichia coli DNA polymerase III holoenzyme

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