A Single Nucleotide Change in the polC DNA Polymerase III in Clostridium thermocellum Is Sufficient To Create a Hypermutator Phenotype

Author:

Lanahan Anthony12,Zakowicz Kamila1,Tian Liang12,Olson Daniel G.12ORCID,Lynd Lee R.12

Affiliation:

1. Thayer School of Engineering at Dartmouth College, Hanover, New Hampshire, USA

2. Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA

Abstract

Cellulosic biofuels are a promising approach to decarbonize the heavy-duty-transportation sector. A longstanding barrier to cost-effective cellulosic biofuel production is the recalcitrance of the material to solubilization.

Funder

HHS | NIH | National Cancer Institute

U.S. Department of Energy

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

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