Salmonella enterica Serovar Typhimurium SPI-1 and SPI-2 Shape the Global Transcriptional Landscape in a Human Intestinal Organoid Model System-Reference-Cited by-同舟云学术

Salmonella enterica Serovar Typhimurium SPI-1 and SPI-2 Shape the Global Transcriptional Landscape in a Human Intestinal Organoid Model System

Published:2021-05-18 Issue: Volume: Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Lawrence Anna-Lisa E.¹,Abuaita Basel H.¹,Berger Ryan P.¹,Hill David R.²,Huang Sha³,Yadagiri Veda K.²,Bons Brooke²,Fields Courtney²,Wobus Christiane E.¹^ORCID,Spence Jason R.²³,Young Vincent B.²^ORCID,O’Riordan Mary X.¹^ORCID

Affiliation:

1. Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA

2. Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA

3. Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA

Abstract

Salmonella enterica serovar Typhimurium ( S . Typhimurium) causes a significant health burden worldwide, yet host responses to initial stages of intestinal infection remain poorly understood.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.00399-21

Reference47 articles.

1. CDC. 2020. Salmonella homepage. CDC Atlanta GA. https://www.cdc.gov/salmonella/index.html. Accessed November 2020.

2. Nramp1 drives an accelerated inflammatory response duringSalmonella-induced colitis in mice

3. Salmonella typhimurium Persists within Macrophages in the Mesenteric Lymph Nodes of Chronically Infected Nramp1+/+ Mice and Can Be Reactivated by IFNγ Neutralization