C6 Hydroxymethyl-Substituted Carbapenem MA-1-206 Inhibits the Major <i>Acinetobacter baumannii</i> Carbapenemase OXA-23 by Impeding Deacylation-Reference-Cited by-同舟云学术

C6 Hydroxymethyl-Substituted Carbapenem MA-1-206 Inhibits the Major Acinetobacter baumannii Carbapenemase OXA-23 by Impeding Deacylation

Published:2022-06-28 Issue:3 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Stewart Nichole K.¹,Toth Marta¹,Alqurafi Maha A.²,Chai Weirui²,Nguyen Thu Q.²,Quan Pojun²,Lee Mijoon¹³,Buynak John D.²,Smith Clyde A.⁴⁵,Vakulenko Sergei B.¹^ORCID

Affiliation:

1. Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA

2. Department of Chemistry, Southern Methodist University, Dallas, Texas, USA

3. Mass Spectrometry and Proteomics Facility, University of Notre Dame, Notre Dame, Indiana, USA

4. Stanford Synchrotron Radiation Lightsource, Stanford University, Menlo Park, California, USA

5. Department of Chemistry, Stanford University, Stanford, California, USA

Abstract

Carbapenem antibiotics are the drugs of choice for treatment of deadly infections caused by Gram-negative bacteria. However, their efficacy is severely compromised by the wide spread of carbapenem-hydrolyzing class D β-lactamases (CHDLs).

Funder

National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Center for Research Resources

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.00367-22

Reference70 articles.

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