Antibody Recognition of CD4-Induced Open HIV-1 Env Trimers-Reference-Cited by-同舟云学术

Antibody Recognition of CD4-Induced Open HIV-1 Env Trimers

Published:2022-12-21 Issue:24 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Yang Zhi¹^ORCID,Dam Kim-Marie A.¹^ORCID,Gershoni Jonathan M.²,Zolla-Pazner Susan³^ORCID,Bjorkman Pamela J.¹^ORCID

Affiliation:

1. Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA

2. Shmunis School of Biomedicine and Cancer Research, Tel Aviv University, Tel Aviv, Israel

3. Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, New York, USA

Abstract

The RV144 HIV-1 clinical vaccination trial showed modest protection against viral infection. Antibody responses to the V1V2 region of HIV-1 Env gp120 were correlated inversely with the risk of infection, and data from three other clinical vaccine trials suggested a similar signal.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Bill and Melinda Gates Foundation

HHS | NIH | National Institute of General Medical Sciences

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01082-22

Reference82 articles.

1. Viral membrane fusion