A Germline-Targeting Chimpanzee SIV Envelope Glycoprotein Elicits a New Class of V2-Apex Directed Cross-Neutralizing Antibodies-Reference-Cited by-同舟云学术

A Germline-Targeting Chimpanzee SIV Envelope Glycoprotein Elicits a New Class of V2-Apex Directed Cross-Neutralizing Antibodies

Published:2023-02-28 Issue:1 Volume:14 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Bibollet-Ruche Frederic¹²,Russell Ronnie M.¹²,Ding Wenge¹²,Liu Weimin¹²,Li Yingying¹²,Wagh Kshitij³,Wrapp Daniel⁴⁵^ORCID,Habib Rumi¹⁶²,Skelly Ashwin N.¹⁶²^ORCID,Roark Ryan S.¹²,Sherrill-Mix Scott¹²,Wang Shuyi¹²,Rando Juliette¹²,Lindemuth Emily¹²,Cruickshank Kendra¹²,Park Younghoon¹²,Baum Rachel¹²,Carey John W.¹²,Connell Andrew Jesse¹²,Li Hui¹²,Giorgi Elena E.³,Song Ge S.⁷,Ding Shilei⁸⁹,Finzi Andrés⁸⁹^ORCID,Newman Amanda⁴⁵,Hernandez Giovanna E.⁴⁵,Machiele Emily⁴⁵,Cain Derek W.⁴⁵,Mansouri Katayoun⁴,Lewis Mark G.¹⁰,Montefiori David C.¹¹,Wiehe Kevin J.⁴⁵,Alam S. Munir⁴⁵^ORCID,Teng I-Ting¹²,Kwong Peter D.¹²^ORCID,Andrabi Raiees⁷,Verkoczy Laurent¹³,Burton Dennis R.⁷¹⁴,Korber Bette T.³,Saunders Kevin O.⁴⁵,Haynes Barton F.⁴⁵,Edwards Robert J.⁴⁵,Shaw George M.¹²^ORCID,Hahn Beatrice H.¹²^ORCID

Affiliation:

1. Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

2. Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA

3. Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, USA

4. Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, USA

5. Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA

6. Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, Pennsylvania, USA

7. Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, USA

8. Centre de Recherche du CHUM, Montreal, Quebec, Canada

9. Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, Quebec, Canada

10. Bioqual, Inc., Rockville, Maryland, USA

11. Department of Surgery, Duke University School of Medicine, Durham, North Carolina, USA

12. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

13. San Diego Biomedical Research Institute, San Diego, California, USA

14. Ragon Institute of MGH, Harvard and MIT, Cambridge, Massachusetts, USA

Abstract

An effective HIV-1 vaccination strategy will need to stimulate rare precursor B cells of multiple bNAb lineages and affinity mature them along desired pathways. Here, we searched for V2-apex germ line-targeting Envs among a large set of diverse primate lentiviruses and identified minimally modified versions of one chimpanzee SIV Env that bound several human V2-apex bNAb precursors and stimulated one of these in a V2-apex bNAb precursor-expressing knock-in mouse.

Funder

CIHR foundation

Canada Research Chair on Retroviral Entry

HHS NIH National Institute of Allergy and Infectious Diseases

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03370-22