Truncation of the Cytoplasmic Tail of Equine Infectious Anemia Virus Increases Virion Production by Improving Env Cleavage and Plasma Membrane Localization-Reference-Cited by-同舟云学术

Truncation of the Cytoplasmic Tail of Equine Infectious Anemia Virus Increases Virion Production by Improving Env Cleavage and Plasma Membrane Localization

Published:2021-11-09 Issue:23 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Wang Xue-Feng¹,Wang Yu-Hong²,Bai Bowen¹,Zhang Mengmeng¹,Chen Jie¹,Zhang Xiangmin¹,Gao Min¹,Wang Xiaojun¹^ORCID

Affiliation:

1. State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, China

2. Department of Geriatrics and Gerontology, First Affiliated Hospital of Harbin Medical University, Harbin, China

Abstract

The mature lentivirus envelope glycoprotein (Env) is composed of a surface unit (SU) and a transmembrane unit (TM), which are cleaved products of the Env precursor. After mature Env is heterodimerically formed from the cleavage of the Env precursor, it is trafficked to the plasma membrane (PM) for incorporation and virion assembly.

Funder

National Natural Science Foundation of China

Postdoctoral Scientific Research Development Fund of Heilongjiang Province

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01087-21

Reference54 articles.

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2. HIV-1 Envelope Glycoprotein Biosynthesis, Trafficking, and Incorporation