Distinct Mechanisms of Dissemination of NDM-1 Metallo-β-Lactamase in Acinetobacter Species in Argentina-Reference-Cited by-同舟云学术

Distinct Mechanisms of Dissemination of NDM-1 Metallo-β-Lactamase in Acinetobacter Species in Argentina

Published:2020-04-21 Issue:5 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Adams Mark D.¹^ORCID,Pasteran Fernando²,Traglia German M.³,Martinez Jasmine⁴,Huang Fanny⁴,Liu Christine⁴,Fernandez Jennifer S.⁴,Lopez Carolina⁵,Gonzalez Lisandro J.⁵⁶,Albornoz Ezequiel²,Corso Alejandra²,Vila Alejandro J.⁵⁶,Bonomo Robert A.⁷⁸⁹¹⁰¹¹,Ramirez Maria Soledad⁴^ORCID

Affiliation:

1. The Jackson Laboratory, Farmington, Connecticut, USA

2. National/Regional Reference Laboratory for Antimicrobial Resistance (NRL), Servicio Antimicrobianos, Instituto Nacional de Enfermedades Infecciosas, ANLIS Dr. Carlos G. Malbrán, Buenos Aires, Argentina

3. Departamento de Desarrollo Biotecnología, Instituto de Higiene, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay

4. Center for Applied Biotechnology Studies, Department of Biological Science, College of Natural Sciences and Mathematics, California State University Fullerton, Fullerton, California, USA

5. Instituto de Biología Molecular y Celular de Rosario (IBR, CONICET-UNR), Rosario, Argentina

6. Área Biofísica, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina

7. Research Service and GRECC, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA

8. Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

9. Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

10. Department of Molecular Biology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

11. Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

Abstract

A 4-year surveillance of carbapenem-resistant Acinetobacter spp. isolates in Argentina identified 40 strains carrying bla NDM-1 . Genome sequencing revealed that most were Acinetobacter baumannii , whereas seven represented other Acinetobacter spp. The A. baumannii genomes were closely related, suggesting recent spread. bla NDM-1 was located in the chromosome of A. baumannii strains and on a plasmid in non- A. baumannii strains.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00324-20

Reference24 articles.

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