Author:
Toleman M. A.,Spencer J.,Jones L.,Walsh T. R.
Abstract
ABSTRACTAlignment of DNA sequences found upstream ofaphA6and allblaNDM-1genes displays 100% identity. This identity continues 19 bp into theblaNDM-1gene such that the first 6 amino acids ofaphA6andblaNDM-1are the same. Furthermore, the percent GC content (GC%) ofaphA6is considerably lower than that ofblaNDM-1and the GC% within theblaNDM-1structural gene changes dramatically after the first 19 bp. This is unequivocal evidence thatblaNDM-1is a chimera.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference20 articles.
1. NDM-2 carbapenemase-producing Acinetobacter baumannii in the United Arab Emirates;Ghazawi;Clin. Microbiol. Infect.,2012
2. A novel variant, NDM-5, of the New Delhi metallo-beta-lactamase in a multidrug-resistant Escherichia coli ST648 isolate recovered from a patient in the United Kingdom;Hornsey;Antimicrob. Agents Chemother.,2011
3. NDM-2 carbapenemase in Acinetobacter baumannii from Egypt;Kaase;J. Antimicrob. Chemother.,2011
4. Crystal structure of New Delhi metallo-beta-lactamase reveals molecular basis for antibiotic resistance;King;Protein Sci.,2011
5. Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study;Kumarasamy;Lancet Infect. Dis.,2010
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