Gene Expression: the Key to Understanding HIV-1 Infection?-Reference-Cited by-同舟云学术

Gene Expression: the Key to Understanding HIV-1 Infection?

Published:2020-05-20 Issue:2 Volume:84 Page:
ISSN:1092-2172
Container-title:Microbiology and Molecular Biology Reviews
language:en
Short-container-title:Microbiol Mol Biol Rev

Author:

Judge Melinda¹,Parker Erica¹,Naniche Denise²³,Le Souëf Peter¹

Affiliation:

1. Faculty of Health and Medical Sciences, University of Western Australia, Perth, Australia

2. Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain

3. Centro de Investigação de Saúde de Manhiça (CISM), Manhiça, Mozambique

Abstract

Gene expression profiling of the host response to HIV infection has promised to fill the gaps in our knowledge and provide new insights toward vaccine and cure. However, despite 20 years of research, the biggest questions remained unanswered. A literature review identified 62 studies examining gene expression dysregulation in samples from individuals living with HIV. Changes in gene expression were dependent on cell/tissue type, stage of infection, viremia, and treatment status. Some cell types, notably CD4 + T cells, exhibit upregulation of cell cycle, interferon-related, and apoptosis genes consistent with depletion.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology,Infectious Diseases

Link

https://journals.asm.org/doi/pdf/10.1128/MMBR.00080-19

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