Joint-specific DNA methylation and transcriptome signatures in rheumatoid arthritis identify distinct pathogenic processes

Author:

Ai Rizi,Hammaker Deepa,Boyle David L.,Morgan Rachel,Walsh Alice M.,Fan Shicai,Firestein Gary S.,Wang Wei

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Reference34 articles.

1. Burmester, G. R., Feist, E. & Dörner, T. Emerging cell and cytokine targets in rheumatoid arthritis. Nat. Rev. Rheumatol. 10, 77–88 (2014).

2. Firestein, G. S. The disease formerly known as rheumatoid arthritis. Arthritis Res. Ther. 16, 114 (2014).

3. Pincus, T. & Castrejón, I. Evidence that the strategy is more important than the agent to treat rheumatoid arthritis. Data from clinical trials of combinations of non-biologic DMARDs, with protocol-driven intensification of therapy for tight control or treat-to-target. Bull. Hosp. Jt. Dis. (2013) 71, (Suppl 1): S33–S40 (2013).

4. Castrejón, I. & Pincus, T. Patient self-report outcomes to guide a treat-to-target strategy in clinical trials and usual clinical care of rheumatoid arthritis. Clin. Exp. Rheumatol. 30, S50–S55 (2012).

5. Guyot, P. et al. Abatacept with methotrexate versus other biologic agents in treatment of patients with active rheumatoid arthritis despite methotrexate: a network meta-analysis. Arthritis Res. Ther. 13, R204 (2011).

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