Specific Assay of Aminoglycosidic- or Polymyxin-Type Antibiotics Present in Human Sera in Combination with Cephalosporins-Reference-Cited by-同舟云学术

Specific Assay of Aminoglycosidic- or Polymyxin-Type Antibiotics Present in Human Sera in Combination with Cephalosporins

Published:1971-06 Issue:6 Volume:21 Page:1002-1006
ISSN:0003-6919
Container-title:Applied Microbiology
language:en
Short-container-title:Appl Microbiol

Author:

Stroy S. Ann¹,Preston David A.¹

Affiliation:

1. The Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46206

Abstract

Monitoring of serum concentrations of aminoglycosidic or polymyxin antibiotics when administered concurrently with cephalosporins or penicillins requires a special assay technique. Selective enzymatic degradation of the β-lactam antibiotic from the serum specimen allows subsequent assay of the antibiotic being monitored. This report gives details of a simple procedure for laboratory production of a crude enzyme capable of degrading cephalosporins or penicillins. An assay procedure for quantitating aminoglycosidic or polymyxin antibiotics after enzymatic degradation of a coexisting β-lactam antibiotic is described.

Publisher

American Society for Microbiology

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

https://journals.asm.org/doi/pdf/10.1128/am.21.6.1002-1006.1971

Reference8 articles.

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3. Cephalothin serum levels in the azotemic patient;Kabins S. A.;Antimicrob. Ag. Chemother.,1965

4. Cephaloridine, laboratory and clinical evaluation;Lane R. A.;Antimicrob. Ag. Chemother.,1967

5. Cephaloridine: chemical and biochemical aspects;Newton G. G. F.;Postgrad. Med. J.,1967

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1. Rapid Gentamicin Bioassay Using a Multiple-Antibiotic-Resistant Strain of Klebsiella pneumoniae;Antimicrobial Agents and Chemotherapy;1973-11

2. Selective Filtration of Antibiotics Through Collodion Membranes;Antimicrobial Agents and Chemotherapy;1973-09

3. Biological Properties of Three 3-Heterocyclic-Thiomethyl Cephalosporin Antibiotics;Antimicrobial Agents and Chemotherapy;1972-03

4. Four-Hour Microbiological Assay of Gentamicin in Serum;Antimicrobial Agents and Chemotherapy;1972-01