Affiliation:
1. Infectious Disease Service of the New England Medical Center Hospitals, Boston, Massachusetts 02111
Abstract
The reversibility of human serum protein binding of oxacillin, nafcillin, and cephalothin was investigated by using a diafiltration technique. While the temperature,
p
H, and protein concentration were kept constant, 20% of the serum volume was exchanged every 4 to 5 min. The binding of all three drugs was rapidly reversible, and the percentage of protein binding remained the same throughout the experiment.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference24 articles.
1. A new approach to studying the protein-binding of penicillins;Acred P.;Nature (London),1963
2. A rapid modified ultrafiltration method for determining serum protein bind.. ing and its application to new penicillins;Bennett J. V.;J. Lab. Clin. Med.,1965
3. Inactivation of penicillin by serum;Bigger J. W.;Lancet,1944
4. Interaction between crystalline penicillin and human plasma proteins;Chow B. F.;Science,1945
5. Nuclear magnetic relaxation study of intermolecular complexes. The mechanism of penicillin binding to serum albumin;Fischer J. J.;J. Amer. Chem. Soc.,1965
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