Klebsiella aerogenes Strain Carrying Drug-Resistance Determinants and a lac Plasmid

Author:

Brenchley Jean E.1,Magasanik Boris1

Affiliation:

1. Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

Abstract

In addition to carrying determinants conferring resistance to at least two antibiotics, chloramphenicol and streptomycin, a Klebsiella aerogenes strain contains a plasmid responsible for increased β-galactosidase activity. The plasmid can be transferred to Escherichia coli and Salmonella typhimurium strains. K. aerogenes segregants without the plasmid grow on lactose one-half as fast as the parent strain and contain only one-tenth to one-fifth as much β-galactosidase.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Reference16 articles.

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4. Transfer of episomic elements to Proteus II. Nature of lac+ Proteus strains isolated from clinical specimens;Falkow S.;J. Bacteriol.,1964

5. Frequency of R factor-mediated multiple drug resistance in Klebsiella and;Hinshaw V.;Aerobacter. Appl. Microbiol.,1969

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