Affiliation:
1. Division of Communicable Disease and Immunology, Walter Reed Army Institute of Research, Washington, D.C.
Abstract
Falkow, Stanley
(Walter Reed Army Institute of Research, Washington, D.C.), J. A.
Wohlhieter, R. V. Citarella, and L. S. Baron
. Transfer of episomic elements to
Proteus
. II. Nature of
lac
+
Proteus
strains isolated from clinical specimens. J. Bacteriol.
88:
1598–1601. 1964.—Strains of
Proteus mirabilis
exhibiting the unusual property of utilizing lactose (
lac
+
) have been reported in clinical material. A genetic examination discloses that the
lac
+
determinants in these
Proteus
strains are associated with an infectious element, P, which is distinct from the sex factor of
Escherichia coli
K-12. The composite genetic element, P-
lac
, is readily transmissible to other enteric species and possesses properties which conform to those of an episomic element of the transfer variety. CsCl density-gradient studies of deoxyribonucleic acid (DNA) extracted from
lac
+
P. mirabilis
indicate that the P-
lac
+
element did not arise in this species, but was acquired from an organism possessing a markedly different DNA base composition.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Reference11 articles.
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3. Episomic element in a strain of Salmonella typhosa;FALKOW S.;J. Bacteriol.,1962
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5. Transfer of episomic elements to Proteus. I. Transfer of F-linked chromosomal determinants;FALKOW S., J.;J. Bacteriol.,1964
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