Human cytomegalovirus infection inhibits cell cycle progression at multiple points, including the transition from G1 to S-Reference-Cited by-同舟云学术

Human cytomegalovirus infection inhibits cell cycle progression at multiple points, including the transition from G1 to S

Published:1996-12 Issue:12 Volume:70 Page:8850-8857
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Lu M¹,Shenk T¹

Affiliation:

1. Department of Molecular Biology, Howard Hughes Medical Institute, Princeton University, New Jersey 08544-1014, USA.

Abstract

Human cytomegalovirus inhibits the growth of human foreskin fibroblast cells by 12 h after infection. Analysis of the cellular DNA content of infected cells by flow cytometry demonstrated that cytomegalovirus does not arrest cell cycle progression at a single point. At least two blockages occur, one of which is in the G1 phase of the cell cycle. The G1 arrest introduced by cytomegalovirus infection blocks S-phase entry after serum stimulation.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.70.12.8850-8857.1996

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