Efficacies of Zinc-Finger-Active Drugs against Giardia lamblia-Reference-Cited by-同舟云学术

Efficacies of Zinc-Finger-Active Drugs against Giardia lamblia

Published:1998-06 Issue:6 Volume:42 Page:1488-1492
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Nash Theodore¹,Rice William G.²

Affiliation:

1. Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892,1 and

2. Laboratory of Antiviral Drug Mechanisms, National Cancer Institute-Frederick Cancer Research and Development Center, SAIC Frederick, Frederick, Maryland 21702-12012

Abstract

ABSTRACT Twenty-nine of 34 (85%) Zn-finger-active compounds at 300 μM or less inhibited the growth of Giardia lamblia . The most active compound, disulfiram (Antabuse), was cidal at 1.23 ± 0.32 μM. In the adult mouse model, significant in vivo activity was demonstrated by increased cure rates and decreased parasite burdens.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.42.6.1488

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5. Gessner P. K. Gessner T. Disulfiram and its metabolite diethyldithiocarbamate 1992 344 345 Chapman & Hall London United Kingdom

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