Cytotoxic Factor in the Blood and Plasma of Animals During Leptospirosis-Reference-Cited by-同舟云学术

Cytotoxic Factor in the Blood and Plasma of Animals During Leptospirosis

Published:1973-09 Issue:3 Volume:8 Page:401-405
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Knight Loren L.¹,Miller Norman G.¹,White Roberta J.¹

Affiliation:

1. Department of Medical Microbiology, University of Nebraska, College of Medicine, Omaha, Nebraska 68105

Abstract

Whole blood and plasma from animals in the acute stage of leptospirosis contained a toxic factor which produced a cytopathic effect on fibroblastic L cell monolayers. Firm adsorption of cytotoxic factor (CTF) to L cells occurred within 1 h. The highest titer of CTF in plasma was reached at 24 h and declined after 48 h after the inoculation of leptospires. Toxic effects were also obtained with intracerebral inoculation of mice with plasma containing CTF. Mice showed signs of motor instability and muscular spasms shortly after inoculation with CTF. Death usually occurred within 1 h.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.8.3.401-405.1973

Reference24 articles.

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