Author:
Silva João José Pereira da,Netto Bernardino Alves de Souza,Lilembaum Walter,Alvim Maria Erbene Amorim Melo,Oliveira Albanita Viana de
Abstract
The hemorrhagic syndrome of leptospirosis was studied in guinea pigs. The study correlates hematological, histopathological and immunohistochemical alterations in sixty animals inoculated by the intraperitoneal route with lml of the culture of virulent strain of Leptospira interrogans serovar copenhageni. Leptospirae antigens were detected by immunoperoxidase, chiefly in liver, kidney and heart muscle capillaries. Possible pathogenic mechanisms responsible for hemorrhagic syndrome are discussed with emphasis on toxic and anoxic attacks causing damage to endothelia, platelet depletion and alterations to hemostasia rates: prothrombin time [FT], partial thromboplastin time [PIT] and fibrinogen concentrations. Tide clinical-laboratoiy picture is compatible with the histopathological observation of disseminated intravascular coagulation [D1C] in most of the guinea pigs from day 4 of infection.
Subject
Infectious Diseases,Microbiology (medical),Parasitology
Reference31 articles.
1. Leptospiral antigens (L. interrogans sero-group icterohaemorrhagiae) in the kidney of experimentally infected guinea pigs and their relation to the pathogenesis of renal injury;Alves VAF;Experimental Pathology,1991
2. The pathological anatomy and pathogenesis of fatal human leptospirosis (Weil's disease);Arean VM;American Journal of Pathology,1962
3. Studies on pathogenesis of the leptospirosis: the behavior of the transaminases and oxidative enzyme in experimental leptospirosis: a histochemical and biochemical essay;Arean VM;American Journal of Tropical Medicine and Hygiene,1964
4. Effect of a plasma cytotoxic factor in leptospirosis on platelets in vivo;Chaperon KM;Thrombosis Research,1979
5. Vascular damage in acute experimental leptospirosis of the guinea pig;De Brito T;Journal of Pathology,1979
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