Production of a hemolytic factor by Candida albicans

Author:

Manns J M1,Mosser D M1,Buckley H R1

Affiliation:

1. Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140.

Abstract

Candida albicans exhibits hemolytic activity when grown on glucose-enriched blood agar. This activity is present on intact organisms, and it is secreted into the culture medium. Hemoglobin released from lysed erythrocytes can restore the transferrin-inhibited growth of C. albicans. We conclude that C. albicans expresses a hemolytic factor which allows it to acquire iron from host erythrocytes.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference19 articles.

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2. Identification of C3d receptors on Candida albicans;Calderone R. A.;Infect. Immun.,1988

3. Reversal of serum fungistasis by addition of iron;Caroline L.;J. Invest. Dermatol.,1964

4. Expression of specific binding sites on Candida with functional and antigenic characteristics of human complement receptors;Edwards J. E.;J. Immunol.,1986

5. Effect of pH and iron concentration on growth of Candida albicans in human serum;Elin R. J.;J. Infect. Dis.,1973

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