In VitroActivity of Novel Gyrase Inhibitors against a Highly Resistant Population of Pseudomonas aeruginosa

Abstract

ABSTRACTThe activity of five novel gyrase inhibitors was evaluated against 303 nonduplicatePseudomonas aeruginosastrains collected from 53 North American institutions. The most active compound, GP-2, displayed MIC50and MIC90values of 1 and 2 μg/ml, respectively. Cross-resistance to other commercially available antipseudomonal compounds was not evident, as no major change was observed in the gyrase inhibitor MIC distribution when stratified by nonsusceptible phenotypes, including the fluoroquinolones and those isolates classified as multidrug resistant (MDR).