Construction of oxygenated 2-azabicyclo[2.2.1]heptanes<i>via</i>palladium-catalyzed 1,2-aminoacyloxylation of cyclopentenes-Reference-Cited by-同舟云学术

Construction of oxygenated 2-azabicyclo[2.2.1]heptanesviapalladium-catalyzed 1,2-aminoacyloxylation of cyclopentenes

Published:2023 Issue:24 Volume:59 Page:3574-3577
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Zhou Haipin¹²,Pan Rui²,Xu Menghua²,Ma Jiao²,Lin Aijun²^ORCID,Yao Hequan²^ORCID

Affiliation:

1. College of Materials & Chemical Engineering, Chuzhou University, 1 West Huifeng Road, Chuzhou, 239000, P. R. China

2. State Key Laboratory of Natural Medicines (SKLNM) and Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, P. R. China

Abstract

A palladium-catalyzed 1,2-aminoacyloxylation of cyclopentene has been described and more structurally diverse bridged aza-bicycles could be readily achieved through further transformation.

Funder

National Natural Science Foundation of China

State Key Laboratory of Natural Medicines

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CC/D2CC06581A

Reference50 articles.

1. Escape from Flatland 2: complexity and promiscuity

2. Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

3. The Use of Conformational Restriction in Medicinal Chemistry

4. The impact of aromatic ring count on compound developability – are too many aromatic rings a liability in drug design?

5. Designing novel building blocks is an overlooked strategy to improve compound quality

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