Emergence of an inhibitor-resistant beta-lactamase (SHV-10) derived from an SHV-5 variant-Reference-Cited by-同舟云学术

Emergence of an inhibitor-resistant beta-lactamase (SHV-10) derived from an SHV-5 variant

Published:1997-04 Issue:4 Volume:41 Page:838-840
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Prinarakis E E¹,Miriagou V¹,Tzelepi E¹,Gazouli M¹,Tzouvelekis L S¹

Affiliation:

1. Department of Bacteriology, Hellenic Pasteur Institute, Athens, Greece.

Abstract

An inhibitor-resistant beta-lactamase (SHV-10), derived from an SHV-5 variant (SHV-9), was found in an Escherichia coli clinical isolate. In SHV-10, Ser-130 was replaced by Gly. The enzyme partially retained its ability to hydrolyze penicillins, but its activity against cephalosporins was drastically reduced. A Ser-130-->Gly mutant of the prototype SHV-5, obtained by site-directed mutagenesis, had properties similar to those of SHV-10.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.41.4.838

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