Novel Mutations within the embB Gene in Ethambutol-Susceptible Clinical Isolates of Mycobacterium tuberculosis-Reference-Cited by-同舟云学术

Novel Mutations within the embB Gene in Ethambutol-Susceptible Clinical Isolates of Mycobacterium tuberculosis

Published:2004-11 Issue:11 Volume:48 Page:4447-4449
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Lee Ann S. G.¹,Othman Siti Noor Khadijah¹,Ho Yu Min¹,Wong Sin Yew²

Affiliation:

1. Division of Medical Sciences, National Cancer Centre

2. Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore, Singapore

Abstract

ABSTRACT Genetic analysis of the embB gene revealed mutations in 17 (68%) of 25 ethambutol (EMB) resistant isolates (M306I, M306V, M306L, Q497R) but also in 4 (20%) of 20 EMB-susceptible isolates of Mycobacterium tuberculosis , namely, an ATG→ATM substitution resulting in M306I, G406N, and the novel alterations M423I and A659T.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.48.11.4447-4449.2004

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