Emergence and Dissemination of Enterobacteriaceae Isolates Producing CTX-M-1-Like Enzymes in Spain Are Associated with IncFII (CTX-M-15) and Broad-Host-Range (CTX-M-1, -3, and -32) Plasmids

Author:

Novais Ângela1,Cantón Rafael12,Moreira Raquel13,Peixe Luísa3,Baquero Fernando12,Coque Teresa M.12

Affiliation:

1. Hospital Universitario Ramón y Cajal, IMSALUD, Madrid, Spain

2. Unidad de Resistencia a Antibióticos y Virulencia Bacteriana asociada al Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain

3. REQUIMTE, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal

Abstract

ABSTRACT The spread of CTX-M-1-like enzymes in Spain is associated with particular plasmids of broad-host-range IncN ( bla CTX-M-32 , bla CTX-M-1 ), IncL/M ( bla CTX-M-1 ), and IncA/C 2 ( bla CTX-M-3 ) or narrow-host-range IncFII ( bla CTX-M-15 ). The identical genetic surroundings of bla CTX-M-32 and bla CTX-M-1 and their locations on related 40-kb IncN plasmids indicate the in vivo evolution of this element.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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