Epidemiology of Plasmid Lineages Mediating the Spread of Extended-Spectrum Beta-Lactamases among Clinical Escherichia coli

Author:

Mahmud Bejan1ORCID,Wallace Meghan A.2,Reske Kimberly A.3,Alvarado Kelly2,Muenks Carol E.2,Rasmussen David A.45,Burnham Carey-Ann D.2367ORCID,Lanzas Cristina8ORCID,Dubberke Erik R.3,Dantas Gautam1269ORCID

Affiliation:

1. The Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA

2. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA

3. Department of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri, USA

4. Department of Entomology and Plant Pathology, North Carolina State University, Raleigh, North Carolina, USA

5. Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, USA

6. Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA

7. Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA

8. Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA

9. Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri, USA

Abstract

The increasing incidence of nosocomial infections with extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli represents a significant threat to public health, given the limited treatment options available for such infections. The rapid ESBL spread is suggested to be driven by localization of the resistance genes on conjugative plasmids.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | Agency for Healthcare Research and Quality

DOD | US Army | MEDCOM | Congressionally Directed Medical Research Programs

HHS | Centers for Disease Control and Prevention

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

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