<i>In vitro</i> activity of meropenem-vaborbactam plus aztreonam against metallo-β-lactamase-producing <i>Klebsiella pneumoniae</i>-Reference-Cited by-同舟云学术

In vitro activity of meropenem-vaborbactam plus aztreonam against metallo-β-lactamase-producing Klebsiella pneumoniae

Published:2024-04-03 Issue:4 Volume:68 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Cienfuegos-Gallet Astrid V.¹²,Shashkina Elena¹,Chu Tingyu¹,Zhu Zhichen¹³,Wang Bingjie¹⁴,Kreiswirth Barry N.¹^ORCID,Chen Liang¹^ORCID

Affiliation:

1. Hackensack Meridian Health Center for Discovery and Innovation, Nutley, New Jersey, USA

2. School of Microbiology, University of Antioquia, Medellín, Colombia

3. The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China

4. Department of Clinical Laboratory Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China

Abstract

ABSTRACT We evaluated the in vitro activity of meropenem-vaborbactam plus aztreonam (MEV-ATM) against 140 metallo-β-lactamase (MBL)-producing Klebsiella pneumoniae isolates. Among them, 25 isolates (17.9%) displayed minimum inhibitory concentrations (MIC) ≥ 8 µg/mL, while 112 (80.0%) had MIC ≤ 2 µg/mL. Genomic analysis and subsequent gene cloning experiments revealed OmpK36 134-135GD-insertion and increased carbapenemase gene ( bla NDM-1 and bla OXA-48-like ) copy numbers are the main factors responsible for MEV-ATM non-susceptibility. Notably, MEV-ATM is actively against aztreonam-avibactam-resistant mutants due to CMY-16 mutations.

Funder

HHS | NIH | NIAID | Division of Intramural Research

Publisher

American Society for Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.01346-23

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