New β-Lactam–β-Lactamase Inhibitor Combinations-Reference-Cited by-同舟云学术

New β-Lactam–β-Lactamase Inhibitor Combinations

Published:2020-12-16 Issue:1 Volume:34 Page:
ISSN:0893-8512
Container-title:Clinical Microbiology Reviews
language:en
Short-container-title:Clin Microbiol Rev

Author:

Yahav Dafna¹²^ORCID,Giske Christian G.³,Grāmatniece Alise³⁴,Abodakpi Henrietta⁵,Tam Vincent H.⁵,Leibovici Leonard²⁶

Affiliation:

1. Infectious Diseases Unit, Rabin Medical Center, Beilinson Hospital, Petah-Tikva, Israel

2. Sackler Faculty of Medicine, Tel-Aviv University, Ramat Aviv, Israel

3. Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden

4. Pauls Stradins University Hospital, University of Latvia, Riga, Latvia

5. Department of Pharmacy Practice and Translational Research, University of Houston College of Pharmacy, Houston, Texas, USA

6. Medicine E, Rabin Medical Center, Beilinson Hospital, Petah-Tikva, Israel

Abstract

The limited armamentarium against drug-resistant Gram-negative bacilli has led to the development of several novel β-lactam–β-lactamase inhibitor combinations (BLBLIs). In this review, we summarize their spectrum of in vitro activities, mechanisms of resistance, and pharmacokinetic-pharmacodynamic (PK-PD) characteristics. A summary of available clinical data is provided per drug. Four approved BLBLIs are discussed in detail. All are options for treating multidrug-resistant (MDR) Enterobacterales and Pseudomonas aeruginosa .

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Microbiology (medical),Public Health, Environmental and Occupational Health,General Immunology and Microbiology,Epidemiology

Link

https://journals.asm.org/doi/pdf/10.1128/CMR.00115-20

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