Testing of Experimental Compounds in a Relapse Model of Tuberculosis Using Granulocyte-Macrophage Colony-Stimulating Factor Gene-Disrupted Mice-Reference-Cited by-同舟云学术

Testing of Experimental Compounds in a Relapse Model of Tuberculosis Using Granulocyte-Macrophage Colony-Stimulating Factor Gene-Disrupted Mice

Published:2009-01 Issue:1 Volume:53 Page:306-308
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Woolhiser Lisa K.¹,Hoff Donald R.¹,Marietta Karen S.¹,Orme Ian M.¹,Lenaerts Anne J.¹

Affiliation:

1. Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523

Abstract

ABSTRACT This study describes an in vivo model for evaluating the sterilizing activity of compounds against persisting Mycobacterium tuberculosis . The initial treatment with isoniazid and rifampin in granulocyte-macrophage colony-stimulating factor gene-disrupted mice reduced the number of bacteria more than 99% within 3 weeks. A subsequent treatment with individual drugs was performed to assess their activity on the 1% of remaining bacilli and disease relapse.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01346-07

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