Expansion of Stem Cell-Like CD4 + Memory T Cells during Acute HIV-1 Infection Is Linked to Rapid Disease Progression-Reference-Cited by-同舟云学术

Expansion of Stem Cell-Like CD4 + Memory T Cells during Acute HIV-1 Infection Is Linked to Rapid Disease Progression

Published:2019-07-15 Issue:14 Volume:93 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Pušnik Jernej¹,Eller Michael A.²³,Tassaneetrithep Boonrat⁴,Schultz Bruce T.¹,Eller Leigh Anne²³,Nitayaphan Sorachai⁵,Kosgei Josphat⁶,Maganga Lucas⁷,Kibuuka Hannah⁸,Alter Galit⁹,Michael Nelson L.²,Robb Merlin L.²³,Streeck Hendrik¹^ORCID

Affiliation:

1. Institute for HIV-1 Research, University Hospital, University Duisburg-Essen, Essen, Germany

2. U.S. Military HIV-1 Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA

3. Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA

4. Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

5. Department of Retrovirology, U.S. Army Medical Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand

6. Kenya Medical Research Institute/Walter Reed Project, Kericho, Kenya

7. Walter Reed Program—Tanzania, Mbeya, Tanzania

8. Makerere University Walter Reed Project, Kampala, Uganda

9. Massachusetts General Hospital, Boston, Massachusetts, USA

Abstract

Understanding the immunopathology of acute HIV-1 infection will help to develop eradication strategies. We demonstrate here that a CD4 + T cell memory subset expands during acute HIV-1 infection, which is associated with disease progression.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00377-19

Reference42 articles.

1. Lessons from acute HIV infection

2. Pathogenesis of HIV infection: what the virus spares is as important as what it destroys

3. Vaccination preserves CD4 memory T cells during acute simian immunodeficiency virus challenge

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