Genotypic and Phenotypic Diversity of the Replication-Competent HIV Reservoir in Treated Patients-Reference-Cited by-同舟云学术

Genotypic and Phenotypic Diversity of the Replication-Competent HIV Reservoir in Treated Patients

Published:2022-08-31 Issue:4 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Nicolas Alexandre¹²,Migraine Julie¹,Dutrieux Jacques¹³,Salmona Maud¹⁴,Tauzin Alexandra¹²,Hachiya Atsuko⁵,Estaquier Jérôme²⁶^ORCID,Molina Jean-Michel¹⁴,Clavel François¹⁴,Hance Allan J.¹,Mammano Fabrizio¹²⁷^ORCID

Affiliation:

1. INSERM U941, Université Paris-Diderot, Paris, France

2. INSERM UMR-1124, Université de Paris, Paris, France

3. Université de Paris, Institut Cochin, INSERM, U1016, CNRS, UMR8104, Paris, France

4. APHP Hôpital Saint-Louis, Paris, France

5. National Hospital Organization Nagoya Medical Center, Nagoya, Japan

6. Centre de Recherche du CHU de Québec, Université Laval, Québec, Quebec, Canada

7. INSERM U1259 MAVIVH, Université de Tours, Tours, France

Abstract

In HIV-infected and effectively treated individuals, integrated proviral genomes may persist for decades. The vast majority of the genomes, however, are defective, and only the replication-competent fraction represents a threat of viral reemergence.

Funder

Agence Nationale de Recherches sur le Sida et les Hépatites Virales

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00784-22

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