Affiliation:
1. Department of Pathology, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel
Abstract
SUMMARY
Since 1998 a lethal disease of carp and ornamental koi (Cyprinus carpio) has afflicted fisheries in North America, Europe, and Asia, causing severe economic losses to the fish farming industry. This review summarizes the isolation and identification of the disease-causing agent and describes the currently known molecular characteristics of this newly isolated virus, distinguishing it from other known large DNA viruses. In addition, we summarize the clinical and histopathological manifestations of the disease. Providing information on the immune response to this virus and evaluating the available means of diagnosis and protection should help to reduce the damage induced by this disease. This review does not discuss the economic aspects of the disease or the debate on whether the disease should be registered; both of these issues were recently reviewed in detail (O. L. M. Haenen, K. Way, S. M. Bergmann, and E. Ariel, Bull. Eur. Assoc. Fish Pathol.
24:
293-307, 2004; D. Pokorova, T. Vesely, V. Piackova, S. Reschova, and J. Hulova, Vet. Med. Czech.
50:
139-147, 2005).
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology,Infectious Diseases
Reference51 articles.
1. Ariav R. S. Tinman I. Paperna and I. Bejerano. 1998. Presented at the EAFP 9th International Conference Rhodes Greece.
2. Balon, E. K. 1995. Origin and domestication of the wild carp, Cyprinus carpio: from Roman gourmets to the swimming flowers. Aquaculture129:3-48.
3. Benmansour, A., and P. de Kinkelin. 1997. Live fish vaccines: history and perspectives. Dev. Biol. Stand.90:279-289.
4. Bercovier, H., Y. Fishman, R. Nahary, S. Sinai, A. Zlotkin, M. Eyngor, O. Gilad, A. Eldar, and R. P. Hedrick. 2005. Cloning of the koi herpesvirus (KHV) gene encoding thymidine kinase and its use for a highly sensitive PCR based diagnosis. BMC Microbiol.5:13.
5. Bretzinger, A., T. Fischer-Scherl, R. Oumouma, R. Hoffmann, and U. Truyen. 1999. Mass mortalities in koi, Cyprinus carpio, associated with gill and skin disease. Bull. Eur. Assoc. Fish Pathol.19:182-185.
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