Quinolone Resistance in Enterotoxigenic Escherichia coli Causing Diarrhea in Travelers to India in Comparison with Other Geographical Areas

Author:

Vila Jordi1,Vargas Martha1,Ruiz Joaquim1,Corachan Manuel2,Jimenez de Anta M. Teresa1,Gascon Joaquim2

Affiliation:

1. Departments of Microbiology1 and

2. Infectious Diseases (Tropical Medicine Unit),2 IDIBAPS (Institut d'Investigacions Biomèdiques August Pı́ i Sunyer), Hospital Clı́nic, School of Medicine, University of Barcelona, Barcelona, Spain

Abstract

ABSTRACT Enterotoxigenic Escherichia coli isolates were identified as a cause of traveler's diarrhea in 82 of 520 (16%) patients and tested for resistance to seven antimicrobial agents. Thirty patients (36%) needed antimicrobial therapy: 17 (56%) for persistence of symptoms and 13 (44%) for severity of symptoms. Ampicillin, tetracycline, and trimethoprim-sulfamethoxazole resistance was high. Chloramphenicol showed moderate activity, and amoxicillin plus clavulanic acid, nalidixic acid, and ciprofloxacin showed very good activity. Five nalidixic acid-resistant strains were isolated, four from patients visiting India.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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