DS86760016, a Leucyl-tRNA Synthetase Inhibitor, Is Active against Mycobacterium abscessus-Reference-Cited by-同舟云学术

DS86760016, a Leucyl-tRNA Synthetase Inhibitor, Is Active against Mycobacterium abscessus

Published:2023-06-15 Issue:6 Volume:67 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Nguyen Thanh Quang¹,Heo Bo Eun¹,Hanh Bui Thi Bich²,Jeon Seunghyeon¹,Park Yujin¹,Choudhary Arunima¹,Lee Sujin³⁴,Kim Tae Ho²,Moon Cheol⁵,Min Sun-Joon³⁴⁶,Jang Jichan¹²^ORCID

Affiliation:

1. Division of Life Science, Department of Bio & Medical Big Data (BK21 Four Program), Research Institute of Life Science, Gyeongsang National University, Jinju, Republic of Korea

2. Division of Applied Life Science (BK21 Four Program), Research Institute of Life Science, Gyeongsang National University, Jinju, Republic of Korea

3. Department of Applied Chemistry, Hanyang University, Ansan, Gyeonggi-do, Republic of Korea

4. Center for Bionano Intelligence Education and Research, Hanyang University, Ansan, Gyeonggi-do, Republic of Korea

5. Department of Clinical Laboratory Science, Semyung University, Jecheon, Republic of Korea

6. Department of Chemical and Molecular Engineering, Hanyang University, Ansan, Gyeonggi-do, Republic of Korea

Abstract

Benzoxaboroles are a new class of leucyl-tRNA synthetase inhibitors. Epetraborole, a benzoxaborole, is a clinical candidate developed for Gram-negative infections and has been confirmed to exhibit favorable activity against a well known pulmonary pathogen, Mycobacterium abscessus .

Funder

Korea Disease Control and Prevention Agency

Korea Health Industry Development Institute

National Research Foundation of Korea

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.01567-22

Reference26 articles.

1. Mycobacterium abscessus: a new antibiotic nightmare