Ceclazepide as novelMycobacterium abscessusinhibitor

Abstract

ABSTRACTThe rise of drug-resistantMycobacterium abscessusposes a significant challenge due to its resistance to current standard treatments, highlighting the urgent need for new antibacterial solutions. In this research, ceclazepide was introduced as a promising agent with strong activity againstM. abscessus. Our findings revealed that ceclazepide effectively suppressed the growth ofM. abscessuswild-type strain, multiple subspecies, and clinical isolates in vitro. Notably, ceclazepide demonstrated the ability to inhibitM. abscessusgrowth within macrophages without causing harm. These results support the potential of ceclazepide as a candidate for further development as a clinical drug to combatM. abscessusinfections effectively.