Target Site Pharmacokinetics of Meropenem: Measurement in Human Explanted Lung Tissue by Bronchoalveolar Lavage, Microdialysis, and Homogenized Lung Tissue-Reference-Cited by-同舟云学术

Target Site Pharmacokinetics of Meropenem: Measurement in Human Explanted Lung Tissue by Bronchoalveolar Lavage, Microdialysis, and Homogenized Lung Tissue

Published:2021-11-17 Issue:12 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Paal Michael¹,Scharf Christina²,Denninger Ann Katrin²,Ilia Luis³,Kloft Charlotte³,Kneidinger Nikolaus⁴,Liebchen Uwe²³,Michel Sebastian⁵,Schneider Christian⁶,Schröpf Sebastian⁷,Schuster Carina¹,Vogeser Michael¹,Weinelt Ferdinand³⁸,Zander Johannes¹⁹,Zoller Michael²,Schroeder Ines²^ORCID

Affiliation:

1. Institute of Laboratory Medicine, University Hospital, LMU Munich, Munich, Germany

2. Department of Anaesthesiology, University Hospital, LMU Munich, Munich, Germany

3. Department of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universitaet Berlin, Berlin, Germany

4. Department of Internal Medicine V, University Hospital, LMU Munich, Comprehensive Pneumology Center, Munich, Germany

5. Clinic of Cardiac Surgery, University Hospital, LMU Munich, Munich, Germany

6. Department of Thoracic Surgery, University Hospital, LMU Munich, Munich, Germany

7. Dr von Hauner Children's Hospital, University Hospital, LMU Munich, Munich, Germany

8. Graduate Research Training Program PharMetrX, Berlin, Germany

9. Laboratory Dr. Brunner, Constance, Germany

Abstract

Pneumonia is one of the most common infections in intensive care patients, and it is often treated with beta-lactam antibiotics. Even if therapeutic drug monitoring in blood is available, it is unclear whether sufficient concentrations are reached at the target site: the lung.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01564-21

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