Different Modes of Action of Naphthyridones in Gram-Positive and Gram-Negative Bacteria-Reference-Cited by-同舟云学术

Different Modes of Action of Naphthyridones in Gram-Positive and Gram-Negative Bacteria

Published:2006-01 Issue:1 Volume:50 Page:385-387
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Buurman Ed T.¹,Johnson Kenneth D.¹,Kelly Roxanne K.²,MacCormack Kathy²

Affiliation:

1. Department of Microbiology

2. Molecular Sciences, Infection Discovery, AstraZeneca R&D Boston, Waltham, Massachusetts 02451

Abstract

ABSTRACT Naphthyridones that were recently described as a class of translation inhibitors in gram-positive bacteria mediate their mode of action via GyrA in Haemophilus influenzae and Escherichia coli . These are the first examples of compounds in which modes of action in different bacterial pathogens are mediated through widely different targets.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.50.1.385-387.2006

Reference16 articles.

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