Antibacterial FabH Inhibitors with Mode of Action Validated in Haemophilus influenzae by in Vitro Resistance Mutation Mapping-Reference-Cited by-同舟云学术

Antibacterial FabH Inhibitors with Mode of Action Validated in Haemophilus influenzae by in Vitro Resistance Mutation Mapping

Published:2016-05-09 Issue:7 Volume:2 Page:456-464
ISSN:2373-8227
Container-title:ACS Infectious Diseases
language:en
Short-container-title:ACS Infect. Dis.

Author:

McKinney David C.¹²,Eyermann Charles J.¹²,Gu Rong-Fang¹²,Hu Jun¹²,Kazmirski Steven L.¹²,Lahiri Sushmita D.¹²,McKenzie Andrew R.¹²,Shapiro Adam B.¹²,Breault Gloria¹²

Affiliation:

1. Infection Innovative Medicines, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States

2. Structure and Biophysics and #Chemistry Innovation Center, Discovery Sciences, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

Link

https://pubs.acs.org/doi/pdf/10.1021/acsinfecdis.6b00053

Reference24 articles.

1. Bacterial β-Ketoacyl-Acyl Carrier Protein Synthase III (FabH) as a Target for Novel Antibacterial Agents Design

2. Recent Advances in the Inhibition of Bacterial Fatty Acid Biosynthesis

3. Mitochondrial fatty acid synthesis and respiration

4. Crystal structures of bacterial FabH suggest a molecular basis for the substrate specificity of the enzyme

5. Structure-Based Design, Synthesis, and Study of Potent Inhibitors of β-Ketoacyl-acyl Carrier Protein Synthase III as Potential Antimicrobial Agents

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