Augmentation of the Riboflavin-Biosynthetic Pathway Enhances Mucosa-Associated Invariant T (MAIT) Cell Activation and Diminishes Mycobacterium tuberculosis Virulence-Reference-Cited by-同舟云学术

Augmentation of the Riboflavin-Biosynthetic Pathway Enhances Mucosa-Associated Invariant T (MAIT) Cell Activation and Diminishes Mycobacterium tuberculosis Virulence

Published:2022-02-22 Issue:1 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Dey Ruchi Jain¹,Dey Bappaditya¹,Harriff Melanie²³,Canfield Elizabeth T.³,Lewinsohn David M.²³,Bishai William R.¹^ORCID

Affiliation:

1. Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

2. VA Portland Health Care System, Portland, Oregon, USA

3. Division of Pulmonary and Critical Care Medicine, Oregon Health & Science University, Portland, Oregon, USA

Abstract

Mucosa-associated invariant T (MAIT) cells are an important subset of innate lymphocytes that recognize microbial ligands derived from the riboflavin biosynthesis pathway and mediate antimicrobial immune responses. Modulated MAIT cell responses have been noted in different forms of tuberculosis.

Funder

Department of Biotechnology, Ministry of Science and Technology, India

HHS | National Institutes of Health

Howard Hughes Medical Institute

US Department of Veteran Affairs Clinical Science Research and Development Program

US Department of Veteran Affairs Biomedical Laboratory

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03865-21