Plasma Membrane Phosphatidylinositol-4-Phosphate Is Not Necessary for Candida albicans Viability yet Is Key for Cell Wall Integrity and Systemic Infection-Reference-Cited by-同舟云学术

Plasma Membrane Phosphatidylinositol-4-Phosphate Is Not Necessary for Candida albicans Viability yet Is Key for Cell Wall Integrity and Systemic Infection

Published:2022-02-22 Issue:1 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Garcia-Rodas Rocio¹^ORCID,Labbaoui Hayet¹,Orange François²,Solis Norma³,Zaragoza Oscar⁴^ORCID,Filler Scott G.³⁵^ORCID,Bassilana Martine¹^ORCID,Arkowitz Robert A.¹^ORCID

Affiliation:

1. Université Côte d’Azur, CNRS, INSERM, Institute of Biology Valrose, Nice, France

2. Université Côte d’Azur, CCMA, Nice, France

3. Institute for Infection and Immunity, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA

4. Mycology Reference Laboratory, National Centre for Microbiology, Health Institute Carlos III, Majadahonda, Madrid, Spain

5. David Geffen School of Medicine at UCLA, Los Angeles, California, USA

Abstract

While the PI-4-kinases PIK1 and STT4 both produce PI(4)P, the former generates PI(4)P at the Golgi cisterna and the latter at the plasma membrane, and these two pools are functionally distinct. To address the importance of plasma membrane PI(4)P in Candida albicans , we generated deletion mutants of the three putative plasma membrane PI-4-kinase complex components and quantified the levels of plasma membrane PI(4)P in each of these strains.

Funder

Spanish Ministry from Science and Innovation

Agence Nationale de la Recherche

Centre National de la Recherche Scientifique

HHS | National Institutes of Health

Institut National de la Santé et de la Recherche Médicale

Université Côte d'Azur

European Union

Publisher

American Society for Microbiology

Subject

Virology,Microbiology