A Functional cra Gene Is Required for Salmonella enterica Serovar Typhimurium Virulence in BALB/c Mice-Reference-Cited by-同舟云学术

A Functional cra Gene Is Required for Salmonella enterica Serovar Typhimurium Virulence in BALB/c Mice

Published:2000-06 Issue:6 Volume:68 Page:3772-3775
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Allen James H.¹,Utley Maryjane¹,van den Bosch Han²,Nuijten Piet²,Witvliet Maarten²,McCormick Beth A.³,Krogfelt Karen A.⁴,Licht Tine Rask⁵,Brown Derek⁶,Mauel Michael¹,Leatham Mary P.¹,Laux David C.¹,Cohen Paul S.¹

Affiliation:

1. Department of Biochemistry, Microbiology, and Molecular Genetics, University of Rhode Island, Kingston, Rhode Island 028811;

2. Bacteriological and Immunological Research and Development, Intervet International, 5830 AA Boxmeer, The Netherlands2;

3. Combined Program in Pediatric Gastroenterology and Nutrition, Harvard Medical School, Massachusetts General Hospital, Charlestown, Massachusetts 021203;

4. Department of Gastrointestinal Infections, Statens Seruminstitut, 2300 Copenhagen,4 and

5. Department of Microbiology, Technical University of Denmark, DK-2800 Lyngby,5 Denmark; and

6. Scottish Salmonella Reference Laboratory, Stobhill NHS Trust, Glasgow G21 3UW, Scotland6

Abstract

ABSTRACT A minitransposon mutant of Salmonella enterica serovar Typhimurium SR-11, SR-11 Fad − , is unable to utilize gluconeogenic substrates as carbon sources and is avirulent and immunogenic when administered perorally to BALB/c mice (M. J. Utley et al., FEMS Microbiol. Lett., 163:129–134, 1998). Here, evidence is presented that the mutation in SR-11 Fad − that renders the strain avirulent is in the cra gene, which encodes the Cra protein, a regulator of central carbon metabolism.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.68.6.3772-3775.2000

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